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Related Experiment Videos

Reversible ceftriaxone-associated biliary pseudolithiasis in children.

U B Schaad1, J Wedgwood-Krucko, H Tschaeppeler

  • 1Department of Paediatrics, University of Berne, Switzerland.

Lancet (London, England)
|December 17, 1988
PubMed
Summary

Ceftriaxone treatment in children can cause gallstones, leading to symptoms in some cases. Discontinuing the antibiotic typically resolves these biliary abnormalities and associated symptoms.

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Current opinion in infectious diseases·2002

Area of Science:

  • Pediatric Medicine
  • Pharmacology
  • Radiology

Background:

  • Ceftriaxone is a widely used antibiotic for serious infections in children.
  • Biliary complications are a potential, though not fully understood, side effect of ceftriaxone therapy.

Purpose of the Study:

  • To investigate the incidence and clinical significance of biliary concrements in pediatric patients receiving ceftriaxone.
  • To assess the reversibility of ceftriaxone-induced biliary abnormalities.

Main Methods:

  • Serial abdominal ultrasonography was conducted on 37 children undergoing treatment with ceftriaxone.
  • Clinical symptoms and ultrasound findings were monitored throughout and after treatment cessation.

Main Results:

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  • Biliary concrements were detected in 16 out of 37 pediatric patients (43%).
  • Three patients experienced symptomatic biliary concrements, with one case complicated by urolithiasis and obstructive ureteropyelectasia.
  • Ultrasound abnormalities and symptoms resolved completely after discontinuing ceftriaxone, with resolution times ranging from 2 to 63 days.

    • Conclusions:

    • Ceftriaxone therapy is associated with a significant incidence of biliary concrement formation in children.
    • These biliary abnormalities are generally reversible upon cessation of the antibiotic.
    • Close monitoring for biliary complications may be warranted in pediatric patients on long-term ceftriaxone treatment.