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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Eosinophils and eosinophil-associated diseases: An update.

Jeremy A O'Sullivan1, Bruce S Bochner1

  • 1Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.

The Journal of Allergy and Clinical Immunology
|October 19, 2017
PubMed
Summary

This review highlights recent advances in eosinophil biology and eosinophil-associated diseases. It summarizes key findings from literature published since 2015 for researchers and clinicians.

Keywords:
Eosinophilopoiesisadipose tissueapoptosisasthmabiologicalschronic rhinosinusitis with nasal polyposiseosinophil subsetseosinophilic gastrointestinal disordergranule biogenesisimmunoregulation

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Area of Science:

  • Allergy and Immunology
  • Cell Biology

Background:

  • Eosinophils play a critical role in allergic inflammation and host defense.
  • Understanding eosinophil biology is crucial for developing targeted therapies for eosinophil-associated diseases.

Purpose of the Study:

  • To provide a concise overview of significant recent advances in eosinophil biology.
  • To highlight key trends and findings relevant to both basic and clinical aspects of eosinophils.
  • To identify important recent literature for clinicians and scientists in the field of allergy and immunology.

Main Methods:

  • A literature search was conducted for articles published since 2015.
  • Key journals included the Journal of Allergy and Clinical Immunology and other high-impact publications.
  • Articles were reviewed, organized, and key findings were summarized.

Main Results:

  • Recent research has expanded our knowledge of eosinophil functions in various diseases.
  • Advances include new insights into eosinophil development, trafficking, and effector mechanisms.
  • Significant progress has been made in understanding the role of eosinophils in conditions like asthma and hypereosinophilic syndromes.

Conclusions:

  • Recent literature provides a more comprehensive understanding of eosinophil biology and its implications in disease.
  • Continued research is essential for translating these findings into improved clinical management of eosinophil-related disorders.
  • This review serves as a valuable resource for staying abreast of the latest developments in eosinophil research.