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CD14-New Tricks of an Old Acquaintance
Florian I Schmidt1, Eicke Latz2
1Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany.
Immunity
|October 19, 2017
Abstract:
Zanoni et al. (2017) show that the LPS receptor CD14 promotes internalization of oxidized phospholipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages. Their findings reveal CD14 as a regulator of responses to infection and damage, relaying context-dependent signals that determine inflammatory cell fate decisions.
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