Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

706
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
706
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

402
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
402
Microbial Nutrition01:28

Microbial Nutrition

1.6K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.6K
Overview of Metabolism01:40

Overview of Metabolism

39.2K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
39.2K
Regulation of Metabolism01:19

Regulation of Metabolism

11.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same author

A protocol for the Teen Bugs study: An integrative, multi-omics approach to understanding the role of the gut microbiome and mesocorticolimbic system in adolescent mental health following early adverse caregiving.

Brain, behavior, & immunity - health·2026
Same author

Consumption of processed foods impairs memory function through dietary advanced glycation end-products.

bioRxiv : the preprint server for biology·2026
Same author

The microbial metabolite imidazole propionate modulates hypothalamic activity and stress-induced behaviors.

Cell host & microbe·2025
Same author

Complex carbohydrate utilization by gut bacteria modulates host food consumption.

Nature communications·2025
Same author

Microbial regulation of serotonin and neuroimmune interactions.

Current opinion in immunology·2025

Related Experiment Video

Updated: Feb 20, 2026

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.9K

Microbes REV up Host Metabolism around the Clock.

Geoffrey N Pronovost1, Elaine Y Hsiao1

  • 1Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Immunity
|October 19, 2017
PubMed
Summary

The gut microbiota influences host metabolism by regulating circadian clock genes. This discovery sheds light on how gut bacteria impact lipid metabolism and body composition.

Area of Science:

  • Microbiology
  • Metabolism
  • Genetics

Background:

  • The microbiome's role in host metabolism is increasingly recognized.
  • Specific mechanisms linking the microbiome to host metabolism are not well understood.

Purpose of the Study:

  • To investigate how the gut microbiota regulates host metabolism.
  • To elucidate the mechanisms by which gut bacteria influence lipid metabolism and body composition.

Main Methods:

  • The study analyzed the impact of gut microbiota on gene expression.
  • Investigated the regulation of circadian-clock genes.

Main Results:

  • Gut microbiota was found to regulate the expression of circadian-clock genes.
  • These alterations in gene expression impact host lipid metabolism.

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

8.0K

Related Experiment Videos

Last Updated: Feb 20, 2026

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

2.9K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

8.0K
  • The findings also link these mechanisms to changes in body composition.

    • Conclusions:

    • The gut microbiota plays a significant role in regulating host circadian rhythms.
    • Microbiome-mediated regulation of circadian-clock genes is a key mechanism influencing host lipid metabolism and body composition.