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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation

Muhammad Riaz Khan1, Shaoxun Xiang1, Zhiyin Song2

  • 1CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui, China.

The EMBO Journal
|October 20, 2017
PubMed

Insights

The tumor suppressor p53 activates a new long noncoding RNA, TRINGS, during glucose starvation. TRINGS protects cancer cells with wild-type p53 from death by inhibiting necrotic signaling pathways.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cellular Stress Response

Background:

  • The tumor suppressor p53 is crucial for preventing cancer.
  • p53 can also protect tumor cells under stress.
  • The role of p53-regulated long noncoding RNAs in this protection is unclear.

Purpose of the Study:

  • To investigate the role of p53-regulated long noncoding RNAs in cancer cell survival under stress.
  • To identify novel lncRNAs regulated by p53 during glucose starvation.

Main Methods:

  • Analysis of p53-regulated gene expression under glucose starvation.
  • Identification and characterization of a novel lncRNA (TRINGS).
  • Investigation of TRINGS's mechanism of action involving STRAP and necrotic signaling pathways.

Main Results:

  • p53 directly upregulates a novel lncRNA, TRINGS, under glucose starvation in human tumor cells.
  • TRINGS inhibits the STRAP-GSK3β-NF-κB necrotic signaling pathway.
  • TRINGS specifically responds to glucose deprivation, not other nutrient stresses.

Conclusions:

  • p53-induced TRINGS is a key regulator of the necrotic pathway.
  • TRINGS promotes the survival of cancer cells with wild-type p53 under glucose stress.
  • This study reveals a novel mechanism of cancer cell adaptation to nutrient deprivation.
Keywords:
STRAPTRINGSglucose starvationnecroptosisp53

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