Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Event-related brain potentials: a window on information processing in schizophrenia.

C C Duncan1

  • 1Unit on Psychophysiology, NIMH, Bethesda, MD 20892.

Schizophrenia Bulletin
|January 1, 1988
PubMed
Summary

Event-related brain potentials, specifically the P300 component, reveal differences in schizophrenia. Auditory P300 may indicate a trait marker, while visual P300 reflects clinical state changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomimetic sensory feedback through peripheral nerve stimulation improves dexterous use of a bionic hand.

Science robotics·2020
Same author

A nosology of disorders of attention.

Annals of the New York Academy of Sciences·2001
Same author

Spontaneously infected cephalohematoma: case report and review of the literature.

The Journal of craniofacial surgery·2001
Same author

Neonatal auditory activation detected by functional magnetic resonance imaging.

Magnetic resonance imaging·2001
Same author

Regional brain volume abnormalities and long-term cognitive outcome in preterm infants.

JAMA·2000
Same author

Outcome of children in the indomethacin intraventricular hemorrhage prevention trial.

Pediatrics·2000

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Schizophrenia is associated with attentional impairments.
  • Event-related potentials (ERPs), particularly the P300 component, are sensitive to cognitive processes.
  • The P300's utility in differentiating trait and state markers in schizophrenia requires further investigation.

Purpose of the Study:

  • To investigate the P300 component's application in studying attentional deficits in schizophrenia.
  • To evaluate P300 differences between schizophrenic patients and healthy controls.
  • To determine if P300 reduction in schizophrenia represents a trait or state marker.

Main Methods:

  • Assessed P300 amplitude in response to auditory stimuli of varying probabilities in schizophrenic patients and controls.

Related Experiment Videos

  • Examined P300 responses (visual and auditory) in schizophrenic patients on and off neuroleptic medication.

    • Main Results:

    • Schizophrenic patients exhibited smaller P300 amplitudes for low-probability auditory stimuli compared to controls.
    • Improvement in clinical state correlated with increased visual P300 amplitude.
    • Auditory P300 amplitude was uncorrelated with clinical state improvement.

    Conclusions:

    • Visual P300 appears to function as a state marker for schizophrenia, reflecting clinical fluctuations.
    • Auditory P300 remains a potential trait marker, suggesting a core deficit in auditory information processing in schizophrenia.
    • Schizophrenia may involve distinct neural processing deficits in auditory and visual modalities.