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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
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[Sepsis-3 : What has been confirmed in therapy?]
S David1, F M Brunkhorst2,3,4
1Klinik für Nieren- und Hochdruckerkrankungen, Internistische Intensivmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. david.sascha@mh-hannover.de.
Der Internist
|October 20, 2017
Summary
Sepsis is a life-threatening condition defined by the new sepsis-3 criteria, emphasizing the body's harmful response to infection and resulting organ dysfunction. This review explains the sepsis-3 definition and the 2017 international guidelines.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pathophysiology
Background:
- Sepsis definition has evolved from early concepts of infection-induced systemic overreaction.
- The term Systemic Inflammatory Response Syndrome (SIRS) has been widely used but is now being re-evaluated.
- A 2016 sepsis task force aimed to establish a more scientifically rigorous definition.
Purpose of the Study:
- To detail the sepsis-3 definition, focusing on pathological host response and organ dysfunction.
- To summarize the 2017 international sepsis guideline.
- To provide expert commentary on the updated sepsis definitions and guidelines.
Main Methods:
- Review of historical sepsis concepts and definitions.
- Analysis of the 2016 sepsis task force recommendations.
- Summary and commentary on the 2017 international sepsis guideline.
Main Results:
- The sepsis-3 definition identifies sepsis as a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Organ dysfunction is a key feature for diagnosing sepsis under the new criteria.
- The 2017 international guideline provides updated recommendations based on the sepsis-3 definition.
Conclusions:
- The sepsis-3 definition offers a more precise understanding of sepsis, integrating host response and organ dysfunction.
- Adherence to the 2017 international guidelines is crucial for optimal sepsis management.
- This review provides clarity on the evolving landscape of sepsis diagnosis and treatment.
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