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Updated: Feb 20, 2026
Focal Laser Ablation of Prostate Cancer: An Office Procedure
Published on: March 30, 2021
Spatial Tracking of Targeted Prostate Biopsy Locations: Moving Towards Effective Focal Partial Prostate Gland
Steven Sidelsky1, Shaan Setia1, Srinivas Vourganti2
1Division of Urology, Rush University Medical Center, 1725 W. Harrison Street, POB III Suite 970, Chicago, IL, 60612, USA.
Abstract:
The ability to selectively characterize, localize, and predict the specific areas of the prostate gland which harbor the worst biologic behavior is requisite for optimal prostate cancer therapy, especially in the emerging field of partial prostate gland ablation (focal therapy). In this manuscript, we highlight contemporary techniques in target tracking for focal therapy planning. Multiparametric magnetic resonance imaging has emerged as a dominant strategy to localize biopsy sites most likely to contain high-grade lesions. In-bore MRI biopsy and MR/US fusion biopsy using cognitive or software-enhanced co-registration have also become the most common strategy to accomplish this technical challenge. Such advances have led to growing optimism in the field of focal therapy for prostate cancer.
Insights
Accurately identifying aggressive prostate cancer areas is key for focal therapy. Advanced imaging and biopsy techniques like MRI and MR/US fusion improve precision in locating high-grade lesions for targeted treatment.
Area of Science:
- Urology
- Oncology
- Medical Imaging
Background:
- Optimal prostate cancer therapy requires precise identification of aggressive areas.
- Focal therapy offers a targeted approach, necessitating accurate localization of high-grade lesions.
Purpose of the Study:
- To highlight contemporary target tracking techniques for focal therapy planning in prostate cancer.
- To discuss the role of advanced imaging in localizing potentially aggressive prostate cancer sites.
Main Methods:
- Review of contemporary techniques in target tracking for focal therapy.
- Emphasis on multiparametric magnetic resonance imaging (mpMRI) for lesion localization.
- Discussion of in-bore MRI biopsy and MR/US fusion biopsy (cognitive and software-enhanced co-registration).
Main Results:
- Multiparametric MRI is a dominant strategy for localizing biopsy sites with high-grade lesions.
- In-bore MRI biopsy and MR/US fusion biopsy are common strategies for precise localization.
- These advances contribute to optimism in focal therapy for prostate cancer.
Conclusions:
- Accurate characterization and localization of aggressive prostate cancer are crucial for focal therapy.
- Advanced MRI and biopsy techniques enhance the precision of focal therapy planning.
- Progress in these areas fuels optimism for the future of prostate cancer focal therapy.
