Related Experiment Video
Updated: Feb 20, 2026
11:14
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
1.9K
Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Anthony Veltri1, Christopher Lang1, Wen-Hui Lien1
1de Duve Institute, Faculty of Medicine, Université Catholique de Louvain, Brussels, Belgium.
Stem Cells (Dayton, Ohio)
|October 20, 2017
Summary
Wnt signaling pathways are crucial for mammalian skin development and the regulation of epidermal stem cells (SCs) during tissue homeostasis. This review details Wnt
Area of Science:
- Dermatology and Stem Cell Biology
Background:
- Mammalian skin forms a protective barrier, with epidermal cells and hair follicles (HFs) undergoing continuous development and regeneration.
- Epidermal stem cells (SCs) in the interfollicular epidermis (IFE) and HF bulge drive tissue renewal.
- Wnt signaling pathways are key extrinsic regulators of epidermal development and SC function.
Purpose of the Study:
- To review the role of Wnt signaling in skin development and SC regulation.
- To explore the crosstalk between Wnt signaling and other pathways in skin homeostasis.
Main Methods:
- Literature review of Wnt signaling in skin biology.
- Analysis of Wnt pathway involvement in epidermal development and SC maintenance.
Main Results:
- Wnt signaling is essential for epidermal stratification and HF formation during development.
- Wnt pathways govern SC proliferation and differentiation in postnatal skin and HF regeneration.
- Potential interactions between Wnt and other signaling cascades in skin homeostasis are identified.
Conclusions:
- Wnt signaling is a central regulator of skin development, SC behavior, and tissue homeostasis.
- Understanding Wnt crosstalk is vital for comprehending complex skin regeneration processes.
More Related Videos
09:16Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
Published on: December 14, 2015
11.9K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
2.3K
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
3.1K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.1K
01:41Non-Canonical Wnt Signaling Pathways
8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
02:54Canonical Wnt Signaling Pathway
10.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
01:19Overview of Regeneration and Repair
5.4K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
5.4K