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[Neurotransmission and the lower urinary tract]
1Service d'Urologie, Centre Hospitalier Mulhouse.
Annales D'Urologie
|January 1, 1988
Summary
This review details neurotransmitter activity in the lower urinary tract, focusing on key substances, their actions, and pathways. It confirms a non-adrenergic, non-cholinergic pathway alongside traditional nervous system pathways.
Area of Science:
- Neuropharmacology
- Urology
- Neuroscience
Context:
- The lower urinary tract's function is regulated by complex neurotransmitter activity.
- Understanding these pathways is crucial for treating urinary dysfunction.
Purpose:
- To review current knowledge on neurotransmitter substances, agonists, antagonists, and metabolic pathways in the lower urinary tract.
- To discuss the site of action for neuropharmacological substances.
- To elucidate the role of different neural pathways in lower urinary tract function.
Summary:
- The paper synthesizes information on major neurotransmitters, their modulators (agonists and antagonists), and metabolic fates.
- It examines where these neuropharmacological agents exert their effects within the lower urinary tract.
- Evidence supports the existence of a distinct non-adrenergic, non-cholinergic (NANC) pathway, operating parallel to the sympathetic adrenergic and parasympathetic cholinergic systems.
Impact:
- Provides a comprehensive overview of lower urinary tract neuropharmacology.
- Highlights the significance of the NANC pathway in urinary tract function and potential therapeutic targets.
- Aids researchers and clinicians in understanding and managing lower urinary tract disorders.