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[Synthesis and antiparasitic activity of arylproprenones in the nitro-5-imidazole series]
L Ouattara1, M Debaert, R Cavier
1Laboratoire de Chimie Thérapeutique et Chimique Organique, Faculté de Pharmacie D'Abidjan, Côte D'Ivoire.
Abstract:
The synthesis of new arylpropenones derived from 1-methyl-5-nitro imidazole is described. The investigation of some antiprotozoal properties has shown that compounds with the groups 4-hydroxyphenyl, 4-chlorophenyl or thiophenyl have trichomonacidal activity similar to that of metronidazole.