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Cardio-ankle vascular index value in dyslipidemia patients affected by cardiovascular risk factors
XiaoXiao Zhao1, Liujin Bo1, Hongwei Zhao1
1a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , China.
Insights
Hypertension significantly increases arterial stiffness in patients with dyslipidemia, as measured by the Cardio-Ankle Vascular Index (CAVI). Diabetes mellitus and smoking did not show a significant impact on CAVI in this study group.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
- Biomarkers of Atherosclerosis
Background:
- Arterial stiffness, assessed by Cardio-Ankle Vascular Index (CAVI), is a key cardiovascular risk factor.
- Dyslipidemia (DLP) is a major contributor to atherosclerosis.
- The influence of hypertension, diabetes mellitus, and smoking on atherosclerosis in DLP patients requires further investigation.
Purpose of the Study:
- To investigate the impact of hypertension, diabetes mellitus, and smoking on arterial stiffness (CAVI) in patients with dyslipidemia (DLP).
Main Methods:
- A cohort of 649 DLP patients (median age 66 years) underwent assessment of fasting plasma glucose, lipid profiles, and CAVI measurement.
- Blood parameters were analyzed using automated enzymatic assays.
- CAVI was measured using the VS-1000 apparatus.
Main Results:
- CAVI showed significant correlations with age, systolic blood pressure, total cholesterol, LDL-cholesterol, and triglycerides.
- No significant difference in CAVI was observed between smokers and non-smokers, or between statin-treated and non-statin-treated subjects.
- CAVI was significantly higher in hypertensive and diabetic subjects compared to their respective control groups; however, age-adjusted CAVI remained significantly higher only in the hypertensive group.
Conclusions:
- Arterial stiffness (CAVI) in DLP patients is significantly increased by hypertension.
- Diabetes mellitus and smoking do not significantly affect CAVI in patients with dyslipidemia.
- Hypertension is a critical factor influencing arterial stiffness in individuals with dyslipidemia.
Background:
Increased arterial stiffness is an independent cardiovascular risk factor in smokers or patients with diabetes mellitus and hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness and atherosclerosis. One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). However, there was a little research about which influence factors such as: hypertension, diabetes mellitus, and smoking could contribute to the atherosclerosis in the subjects withDLP.
Methods:
A total of 649 subjects with DLP (Male328/Female321) from Vascular Medicine of Peking University Shougang Hospital were examined, with a median age of 66 and 5-95 percentile range 47.0-83.5 years. Fasting plasma glucose (FPG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) were analyzed by colorimetric enzymatic assays with the use of an auto analyzer (HITACHI-7170, Hitachi, Tokyo, Japan).CAVI was measured by VS-1000 apparatus.
Results:
CAVI correlated significantly with age (p<0.001), Systolic (p<0.001) blood pressure(BP), Total cholesterol (p<0.001), LDL-cholesterol (p<0.001),Triglycerides (p<0.001) . There was no significant difference in CAVI between smokers and non-smokers (p = 0.08) and between statin-treated subjects than in those without statins (p = 0.247). CAVI was significantly higher in subjects with hypertension than in the normotensive group (p<0.001) and in mellitus subjects than in those without mellitus (p<0.001);however, CAVI values adjusted for age was higher only in hypertension than in the normotensive group (p<0.001).
Conclusions:
Our study demonstrated that CAVI value in DLP patients is not significantly affected by diabetes mellitus and smoking, but is increased by hypertension.
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