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Updated: Feb 20, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Clinical Aspects of Miscarriage.
Marie A Walter1, Mary S Alvarado
1Marie A. Walter is the Lead Educator, Resolve Through Sharing, Gundersen Health System/Gundersen Medical Foundation, La Crosse, WI. The author can be reached via e-mail at mawalter@gundersenhealth.org Mary S. Alvarado is a Staff Physician, Obstetrics & Gynecology, Gundersen Health System, La Crosse, WI.
Miscarriage affects 750,000-1 million US women annually. Nurses need to understand clinical and emotional care for early pregnancy loss, regardless of the healthcare setting.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Nursing
Background:
- An estimated 750,000 to 1,000,000 miscarriages occur annually in the United States.
- Women experiencing miscarriage present across various healthcare settings, including prenatal clinics, emergency departments, and labor and birth units.
Purpose of the Study:
- To review the clinical aspects of miscarriage.
- To outline the essential emotional care required for families experiencing early pregnancy loss.
Main Methods:
- Literature review of clinical management of miscarriage.
- Synthesis of best practices for emotional support in early pregnancy loss.
Main Results:
- Miscarriage is the most common cause of early pregnancy loss.
- Nurses require comprehensive knowledge of both clinical management and psychosocial support.
Conclusions:
- Nurses in all medical center areas must be prepared to guide and support families through miscarriage.
- Understanding clinical and emotional aspects is crucial for effective patient care during early pregnancy loss.
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