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Updated: Feb 20, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Oral Hypoglycemic Agents Added to Insulin Monotherapy for Type 2 Diabetes
Rimke C Vos1, Guy E H M Rutten1
1Julius Center for Health Sciences and Primary Care, Department of General Practice, University Medical Center Utrecht, Utrecht, the Netherlands.
Clinical Question:
Among patients with type 2 diabetes mellitus who do not achieve optimal glycemic control with insulin monotherapy, is the addition of oral hypoglycemic agents associated with benefits (measured by lowering of hemoglobin A1c) or adverse effects?
Bottom Line:
Adding a sulfonylurea to insulin was associated with more hypoglycemic events compared with insulin alone, but this association was not observed for metformin. Adding a sulfonylurea or metformin to insulin was associated with a decrease in hemoglobin A1c of approximately 1.0%.
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