Related Experiment Video

Updated: Feb 20, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.5K

Does mitral valve repair matter in infants with ventricular septal defect combined with mitral regurgitation?

Yuriy Y Kulyabin1, Ilya A Soynov1, Alexey V Zubritskiy1

  • 1Department of Pediatric Cardiac Surgery, Siberian Biomedical Research Center, Ministry of Health Russian Federation, Novosibirsk, Russian Federation.

Interactive Cardiovascular and Thoracic Surgery
|October 20, 2017
PubMed

Insights

Simultaneous mitral valve repair (MVR) offers no advantage for infants with ventricular septal defect (VSD) and mitral regurgitation (MR) compared to VSD closure alone. Mild residual MR post-surgery predicts future moderate to severe MR.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Cardiac Surgery Outcomes

Background:

  • Ventricular septal defect (VSD) is a common congenital heart defect.
  • Mitral regurgitation (MR) can coexist with VSD, complicating surgical management.
  • The efficacy of simultaneous mitral valve repair (MVR) alongside VSD closure requires evaluation.

Purpose of the Study:

  • To assess mid-term mitral valve function following combined VSD repair and MVR.
  • To determine the clinical utility of performing MVR concurrently with VSD closure.
  • To identify factors influencing mitral regurgitation progression post-surgery.

Main Methods:

  • Retrospective analysis of 60 patients with VSD and MR from June 2005 to March 2014.
  • Propensity score matching (1:1) created two groups: VSD closure with MVR (n=23) and VSD closure only (n=23).
  • Mid-term follow-up (12-48 months) assessed mitral valve function and recurrence of MR.

Main Results:

  • No significant difference in postoperative mortality or short-term recovery between groups.
  • Longer cardiopulmonary bypass and aortic cross-clamping times were observed in the VSD+MVR group.
  • No significant difference in freedom from moderate or severe MR (MR ≥ 2+) between groups.
  • Mild residual MR in the early postoperative period was the sole significant predictor of recurrent MR ≥ 2+.

Conclusions:

  • Simultaneous MVR provides no additional benefit over isolated VSD closure for patients with VSD and MR.
  • The presence of mild residual MR postoperatively is a critical risk factor for developing significant MR during follow-up.
  • Focusing on achieving complete early MR correction is crucial for long-term outcomes.
Abstract

Keywords:
Congenital valve malformationsMitral valve repairVentricular septal defect

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

2.5K
An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.6K

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
662
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
390
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
827
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
407
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
651
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
335