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Updated: Feb 20, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Learn from microbial intelligence for avermectins overproduction
Qiang Gao1, Gao-Yi Tan2, Xuekui Xia3
1Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Abstract:
Microbial strains are amazingly clever by homeostasis of their own survival and optimization for the overproduction of a desired phenotype, for example drugable secondary metabolites through coordination of key genes overexpression and media optimizations. Besides their pesticide activities, avermectins (AVMs) are identified as potent antibiotic agents for a wide range of drug-resistant pathogens by a high-throughput synergy screening strategy. To rewire the genetic circuitry controlling low yields, we summarized the work on balancing the biological chassis with functional parts, and optimized their dynamical process, as well as predicted favorable effective overproduction of AVMs by 5Ms strategy. AVMs are exclusively made in China now and intelligences learned from the success of AVMs will help transform microbes into a true power-house of innovation.
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