[Altered expression and clinical significance of plasma PDGF in patients with myasthnia gravis]

Objective: To evaluate the expression and clinical significance of plasma platelet derived growth factor (PDGF) in the patients with myasthenia gravis (MG). Methods: Plasma samples from 44 MG patients and 34 healthy people were collected from August 2015 to December 2016 from the Second Affiliated Hospital of Harbin Medical University. The expression of PDGF was detected by MILLIPLEX MAP Reagent kit. Furthermore, we analyzed the associations between PDGF expression level and quantitative myasthenia gravis score (QMG). Result: The expression of PDGF in plasma was significant lower in MG patients (5.8±1.3) compared with control group (10.1±2.2), and the difference was statistically significant (t'=-9.767, P<0.001). Meanwhile it was positively related to QMG (r=0.777, P<0.01). However, no significant difference in expression of PDGF in MG subgroups was observed. Conclusion: The expression of PDGF decreases in MG patients, has positive correlation with MG severity, and is not related to age, sex and the pathology of thymus samples.