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Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy
Bratislavske Lekarske Listy
|October 21, 2017
Summary
The neutrophil-to-lymphocyte ratio (NLR) is elevated in thyroid ophthalmopathy (TO) patients compared to controls. Higher NLR levels indicate more severe inflammation in active TO.
Area of Science:
- Ophthalmology
- Endocrinology
- Immunology
Background:
- Thyroid ophthalmopathy (TO) is an autoimmune condition affecting the eyes.
- Assessing inflammation severity in TO is crucial for patient management.
Purpose of the Study:
- To investigate the utility of the neutrophil-to-lymphocyte ratio (NLR) as a biomarker for inflammation severity in thyroid ophthalmopathy (TO).
Main Methods:
- The study included 56 TO patients (24 active, 32 inactive) and 40 healthy controls.
- Neutrophil and lymphocyte counts were measured to calculate the NLR.
- Clinical activity score (CAS) was used to categorize TO activity.
Main Results:
- Neutrophil-to-lymphocyte ratio (NLR) levels were significantly higher in TO patients compared to healthy controls.
- NLR values were significantly elevated in the active TO group relative to the inactive TO group.
- White blood cell, neutrophil, and lymphocyte counts were also higher in TO patients.
Conclusions:
- Neutrophil-to-lymphocyte ratio (NLR) serves as a valuable indicator of inflammation in thyroid ophthalmopathy (TO).
- Elevated NLR levels correlate with increased disease activity and severity in TO patients.
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