Related Experiment Video

Updated: Feb 20, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Pediatric Kikuchi-Fujimoto disease: A clinicopathologic study and the therapeutic effects of hydroxychloroquine

Yung-Chih Lin1, Hsiu-Hui Huang2, Bao-Ren Nong3

  • 1Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|October 21, 2017
PubMed

Insights

Kikuchi-Fujimoto disease (KFD) in children often presents with febrile cervical lymphadenopathy. Hydroxychloroquine showed favorable effects and safety as a treatment option for KFD.

Area of Science:

  • Pediatric Infectious Diseases
  • Rheumatology
  • Dermatology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition that primarily affects lymph nodes.
  • Accurate diagnosis and effective treatment strategies for pediatric KFD are crucial.

Purpose of the Study:

  • To delineate the clinical characteristics of Kikuchi-Fujimoto disease in pediatric patients.
  • To evaluate the efficacy and safety of hydroxychloroquine as a monotherapy for KFD in children.

Main Methods:

  • Retrospective review of medical records for pediatric KFD cases diagnosed between January 1992 and September 2016.
  • Analysis of clinical presentations, laboratory findings, histopathological features, and treatment outcomes.

Main Results:

  • Forty pediatric patients with histopathologically confirmed KFD were analyzed (mean age 13.9 years).
  • Common symptoms included cervical lymphadenopathy (95%), fever, cough, and leukopenia (56.5%) with monocytosis (63.6%).
  • Hydroxychloroquine monotherapy in five patients resulted in no recurrences or significant adverse effects.

Conclusions:

  • Febrile cervical lymphadenopathy with leukopenia and monocytosis should raise suspicion for KFD in children.
  • Specific laboratory and histopathological findings can predict prolonged fever.
  • Hydroxychloroquine presents a safe and effective alternative to corticosteroids for KFD treatment in children.
Abstract

Keywords:
HistopathologyHydroxychloroquineKikuchi-Fujimoto diseasePediatric

More Related Videos

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

17.5K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
298
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
580
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
269
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
362
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
350
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
500