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Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar
Paul Roux1, Aurélie Raust2, Anne-Sophie Cannavo2
1Paul Roux, MD, PhD, Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, Le Chesnay, Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone veil, Université de Versailles Saint-Quentin-En-Yvelines, Montigny-le-Bretonneux and Fondation Fondamental, Créteil, France; Aurélie Raust, MSc, Fondation Fondamental, Créteil, AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil, Université Paris Est, Faculté de Médecine, Créteil and Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil, France; Anne-Sophie Cannavo, MSc, Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, Le Chesnay, Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone veil, Université de Versailles Saint-Quentin-En-Yvelines, Montigny-le-Bretonneux and Fondation Fondamental, Créteil, France; Valérie Aubin, MD, PhD, Fondation Fondamental, Créteil and Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco, France; Bruno Aouizerate, MD, PhD, Fondation Fondamental, Créteil and Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux; Jean-Michel Azorin, MD, PhD, Fondation Fondamental, Créteil and AP-HM, Hôpital Sainte-Marguerite, Pôle de Psychiatrie, Marseille, France; Frank Bellivier, MD, PhD, Fondation Fondamental, Créteil, AP-HP, GH Saint-Louis - Lariboisière - Femand widal, Pôle Neurosciences, Paris and Université Paris Diderot, UMR-S, Paris; Raoul Belzeaux, MD, PhD, Fondation Fondamental, Créteil and AP-HM, Hopital Sainte-Marguerite, Pole de Psychiatrie, Marseille, France; Thierry Bougerol, MD, Fondation Fondamental, Créteil, University Grenoble Alpes, Grenoble, CHU de Grenoble et des Alpes, Grenoble and Grenoble Institut des Neurosciences (GIN) Inserm U 836, La Tronche, France; Iréna Cussac, MD, Fondation Fondamental, Créteil and Pôle de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco, France; Philippe Courtet, MD, PhD, Fondation Fondamental, Créteil, Department of Emergency Psychiatry & Post Acute Care, Academic hospital of Montpellier, Montpellier University, Montpellier and 16 INSERM U1061, Montpellier, France; Bruno Etain, MD, PhD, Fondation Fondamental, Créteil, AP-HP, GH Saint-Louis - Lariboisière - Fernand widal, Pôle Neurosciences, Paris, 11 Université Paris Diderot, UMR-S, Paris, France and Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Sébastien Gard, MD, Fondation Fondamental, Créteil and Centre Expert Trouble Bipolaire, Pôle de Psychiatrie Générale et Universitaire (3/4/7), Hôpital Charles Perrens, Bordeaux; Sophie Job, MD, Fondation Fondamental, Créteil and Pôle de Psychiatrie et Psychologie Clinique - Centre Psychothérapique de Nancy, Laxou, France; Jean-Pierre Kahn, MD, PhD, Fondation Fondamental, Créteil, Pôle de Psychiatrie et Psychologie Clinique - Centre Psychothérapique de Nancy, Laxou and Université de Lorraine, Nancy, France; Marion Leboyer, MD, PhD, Fondation Fondamental, Créteil, AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil, Université Paris Est, Faculté de Médecine, Créteil and Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil, France; Emilie Olié, MD, PhD, Fondation Fondamental, Créteil, Department of Emergency Psychiatry & Post Acute Care, Academic hospital of Montpellier, Montpellier University, Montpellier and 16 INSERM U1061, Montpellier, France; Chantal Henry, MD, PhD, Fondation Fondamental, Créteil, AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de Psychiatrie et d'Addictologie, Créteil, Université Paris Est, Faculté de Médecine, Créteil, Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil and Institut Pasteur, Unité Perception et Mémoire, Paris, France; Christine Passerieux, MD, PhD, Service Universitaire de Psychiatrie d'Adultes, Centre Hospitalier de Versailles, Le Chesnay, Laboratoire HandiRESP, EA4047, UFR des Sciences de la Santé Simone veil, Université de Versailles Saint-Quentin-En-Yvelines, Montigny-le-Bretonneux and Fondation Fondamental, Créteil, France paul.roux@uvsq.fr.
Abstract:
BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.
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