[Plasma digoxin levels following treatment with metaclazepam]

Nine cardiac patients treated with digitalis participated in a 3-week study with the aim to investigate whether digoxin (beta-acetyldigoxin) interacts with the new 1,4-benzodiazepine metaclazepam. Comparison of the plasma digoxin levels under placebo and metaclazepam treatment showed no statistically significant differences, i.e. no interactions between digoxin and metaclazepam were found.