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Related Experiment Video

Updated: Feb 20, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Melanoma in pregnancy.

Rebecca Still¹, Shaun Brennecke^2,3

¹Monash Health, Victoria, Australia.

Obstetric Medicine

|October 21, 2017

Summary

Melanoma during pregnancy requires vigilant skin lesion evaluation due to high metastatic potential. Early diagnosis and biopsy of changing lesions are crucial for improved outcomes in pregnant patients.

Keywords:

Pregnancy malignancy melanoma

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Published on: September 7, 2013

Area of Science:

Oncology
Dermatology
Obstetrics

Background:

Melanoma is a frequent cancer diagnosis during pregnancy.
Pregnancy-associated melanoma presents a high risk for metastasis.
There is ongoing debate regarding survival rates for melanoma diagnosed during pregnancy.

Purpose of the Study:

To emphasize the importance of early diagnosis for melanoma in pregnancy.
To highlight the need for biopsy of any changing pigmented lesions, irrespective of pregnancy-related skin changes.
To discuss management considerations, including hormonal influences and future pregnancy planning.

Main Methods:

Review of current literature on pregnancy-associated melanoma.
Clinical guidelines for skin lesion evaluation during pregnancy.
Discussion of diagnostic challenges and treatment implications.

Main Results:

Increased lymphangiogenesis during pregnancy correlates with heightened metastasis risk.
Biopsy of any changing pigmented lesion is recommended, even with physiological hyperpigmentation.
Oral contraceptive use is generally considered safe post-melanoma diagnosis in pregnancy.

Conclusions:

Timely diagnosis of melanoma during pregnancy is imperative due to metastatic potential.
Management requires careful evaluation of suspicious lesions and consideration of hormonal effects.
Delayed subsequent pregnancies are advised for high-risk melanoma cases.