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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Related Experiment Video

Updated: Feb 20, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Current Progress in EBV-Associated B-Cell Lymphomas.

Yonggang Pei1, Alexandria E Lewis1, Erle S Robertson2

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, and Microbiology, Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3610 Hamilton Walk, 201E Johnson Pavilion, Philadelphia, PA, 19104, USA.

Advances in Experimental Medicine and Biology
|October 21, 2017
PubMed
Summary
This summary is machine-generated.

Epstein-Barr virus (EBV) drives B-cell lymphomas through complex molecular mechanisms. Advances in sequencing and mouse models improve understanding and treatment strategies for these viral-associated cancers.

Keywords:
B-cell lymphomasEpstein-Barr virusLatent infection

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Area of Science:

  • Oncology
  • Virology
  • Genetics

Background:

  • Epstein-Barr virus (EBV), identified over 50 years ago, is a significant cause of viral-associated cancers, particularly B-cell lymphomas.
  • EBV-associated lymphomagenesis remains a critical area of research due to its diverse pathologies.

Purpose of the Study:

  • To review recent advancements in understanding EBV-associated B-cell lymphomas.
  • To focus on molecular mechanisms, in vivo studies, and therapeutic strategies.

Main Methods:

  • High-throughput next-generation sequencing technologies.
  • In vivo mouse models for studying lymphomagenesis.
  • Analysis of transcriptional regulation and chromosome aberrations.

Main Results:

  • Significant progress in understanding the molecular drivers of EBV-mediated cancers.
  • Development of novel therapeutic intervention strategies.
  • Insights into EBV's role in B-cell lymphoma development.

Conclusions:

  • Continued research is vital for combating EBV-associated B-cell lymphomas.
  • Integration of genomic and in vivo data enhances therapeutic development.
  • Targeting viral-associated lymphomas shows promise for improved patient outcomes.