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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Related Experiment Video

Updated: Feb 20, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Animal Models in Translational Research: Rosetta Stone or Stumbling Block?

Jessica A Bolker¹

¹Department of Biological Sciences, University of New Hampshire, Durham, NH, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|October 21, 2017

Summary

Animal models are vital for translational research but can hinder progress. Addressing their limitations by diversifying models and focusing on human biology is crucial for overcoming research impasses.

Failed At:

2026-06-19T13:28:08.183362+00:00

Keywords:

animal models translational research validity

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