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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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MERS, SARS and other coronaviruses as causes of pneumonia

Yudong Yin1, Richard G Wunderink2

  • 1Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Respirology (Carlton, Vic.)
|October 21, 2017
PubMed

Insights

Human coronaviruses (HCoVs), once considered minor pathogens, are now recognized as significant threats following SARS and MERS outbreaks. This review details the epidemiology, pathogenesis, and clinical features of these important respiratory viruses.

Area of Science:

  • Infectious Diseases
  • Virology
  • Public Health

Background:

  • Human coronaviruses (HCoVs) were historically viewed as minor respiratory pathogens.
  • The emergence of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) has elevated HCoVs to global health concern.
  • HCoVs are now recognized as significant agents of respiratory tract infections.

Purpose of the Study:

  • To review the epidemiology of human coronavirus infections.
  • To examine the pathogenesis of SARS-CoV, MERS-CoV, and other HCoVs.
  • To describe the clinical characteristics associated with various HCoV infections.

Main Methods:

  • Literature review of epidemiological data.
  • Analysis of pathogenesis studies.
  • Compilation of clinical case reports and series.

Main Results:

  • HCoVs exhibit diverse epidemiological patterns globally.
  • Pathogenesis involves viral entry, replication, and host immune response.
  • Clinical presentations range from mild respiratory illness to severe pneumonia.

Conclusions:

  • HCoVs represent a spectrum of respiratory pathogens with significant public health implications.
  • Understanding HCoV epidemiology, pathogenesis, and clinical features is crucial for effective management.
  • Further research is needed to address emerging HCoV threats.
Keywords:
Middle East respiratory syndromehuman coronavirusespneumoniasevere acute respiratory syndrome

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