Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proofreading

Proofreading

Proofreading

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

Mismatch Repair

Mismatch Repair

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Storage and export of microbial biomass across the western Greenland Ice Sheet.

Nature communications·2021

Same author

The α2,3-selective potentiators of GABA<sub>A</sub> receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development.

Pharmacology, biochemistry, and behavior·2020

Same author

The α2,3-selective potentiator of GABA<sub>A</sub> receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats.

Pharmacology, biochemistry, and behavior·2019

Same author

Two's company, three's a crowd: co-occurring pollinators and parasite species in Breynia oblongifolia (Phyllanthaceae).

BMC evolutionary biology·2018

Same author

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA<sub>A</sub> receptors: Improved bioavailability enhances anticonvulsant efficacy.

Neuropharmacology·2018

Same author

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA<sub>A</sub> receptors.

Pharmacology, biochemistry, and behavior·2018

Same journal

Differential Immune Responses Correlate With Chytridiomycosis Severity in Italian Crested Newts.

Molecular ecology·2026

Same journal

Demography and Environment Shapes Genetic Variation: Spatiotemporal Genetic Dynamics in Cyclic Voles at Low Latitudes.

Molecular ecology·2026

Same journal

Gut Microbiome-Metabolome Reconfiguration Associates With Phenotypic Plasticity of Daphnia Under Predation Risk.

Molecular ecology·2026

Same journal

Population Genomics Highlight the Vulnerability of Coral-Dwelling Gobies to Ecological Losses due to Climatic Disturbances.

Molecular ecology·2026

Same journal

Ancient Divergences of the Maritime Alpine Tree Larix lyallii (Pinaceae) Contrasts With Patterns in Other Pacific Northwest Coastal Disjuncts.

Molecular ecology·2026

Same journal

Ontogenetic Sequence of Differential Gene Expression in Predator-Induced Daphnia pulex.

Molecular ecology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 20, 2026

Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy

Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy

Published on: June 16, 2022

Erratum

C T Darwell, J M Cook

Molecular Ecology

|October 21, 2017

Summary

No abstract available in PubMed .

More Related Videos

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Related Experiment Videos

Last Updated: Feb 20, 2026

Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy

Transcorporal Artificial Urinary Sphincter Cuff Placement in a Case Requiring Revision for Urethral Atrophy

Published on: June 16, 2022

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

Published on: June 17, 2014

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025