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Circadian rest-activity rhythm in chronic obstructive pulmonary disease
Deuzilane Muniz Nunes1, Bruno S B Gonçalves2, Carina Aparecida Tardelli Peixoto3
1a Department of Pharmacy , Universidade Federal do Vale do São Francisco , Petrolina , Pernambuco , Brazil.
Chronobiology International
|October 21, 2017
Summary
Circadian rest-activity rhythm is fragmented in COPD patients, showing disrupted daily patterns. This fragmentation may impact disease management and warrants further investigation into chronotherapy.
Area of Science:
- Chronobiology
- Pulmonary Medicine
- Sleep Science
Background:
- Circadian rhythm disruptions are increasingly recognized in chronic diseases.
- Chronic Obstructive Pulmonary Disease (COPD) significantly impacts daily functioning and quality of life.
- Understanding rest-activity patterns is crucial for managing COPD symptoms.
Purpose of the Study:
- To investigate and characterize the circadian rest-activity rhythm in patients with COPD.
- To compare rhythm fragmentation and stability between COPD patients and healthy controls.
Main Methods:
- Actimetry was used to assess rest-activity patterns in 26 COPD patients and 15 controls.
- Key metrics included intradaily variability (IV) for fragmentation and interdaily stability (IS) for synchronization.
- Relative amplitude mean (RAm) was calculated using M10 (most active 10h) and L5 (least active 5h) activity levels.
Main Results:
- COPD patients exhibited significantly higher intradaily variability (IVm) compared to controls, indicating increased rhythm fragmentation.
- Patients with COPD showed higher activity during the least active 5-hour period (L5).
- A lower relative amplitude mean (RAm) was observed in COPD patients, suggesting reduced amplitude of the rest-activity rhythm.
Conclusions:
- COPD is associated with significant fragmentation of the circadian rest-activity rhythm.
- Disrupted daily rhythms in COPD patients may contribute to symptom burden and reduced quality of life.
- Further research into chronotherapy interventions for COPD is recommended.
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