Ovarian tumors in pregnancy

Area of Science:

• Obstetrics and Gynecology
• Reproductive Medicine
• Surgical Oncology

Background:

• Ovarian tumors diagnosed during pregnancy present unique management challenges.
• Tumor size exceeded 5 cm in all evaluated cases.
• The incidence of ovarian tumors during pregnancy was 1 in 2328 deliveries.

Purpose of the Study:

• To evaluate the outcomes of surgical management for ovarian tumors during pregnancy.
• To assess the efficacy of progestational therapy in preventing pregnancy loss.
• To determine the long-term fertility impact after treatment.

Main Methods:

• Retrospective analysis of 38 women operated for ovarian tumors during pregnancy.
• Comparison of abortion rates between untreated and hydroxy-progesterone-caproate (HPC) treated groups.
• Evaluation of pregnancy outcomes based on HPC dosage.

Main Results:

• Abortion rates were 85.7% in untreated vs. 10% in HPC-treated groups (P<0.02).
• Pregnancies receiving >300 mg HPC resulted in live births in 90% of cases.
• Ovarian malignancies occurred in 5.3% of cases, with 42.9% experiencing later fertility issues.

Conclusions:

• Early surgical intervention for ovarian tumors during pregnancy is recommended.
• Progesterone therapy, particularly with adequate HPC dosage, minimizes abortion risk.
• Prophylactic antibiotics are advised, and long-term fertility should be monitored.