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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
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[Lacosamide (vimpat). Prospects for clinical application].

I G Rudakova1, P N Vlasov2, L V Lipatova3

  • 1Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|October 21, 2017
PubMed
Summary

Lacosamide (LCM) is an effective and well-tolerated treatment for focal epilepsy, showing benefits in long-term use, patient retention, and specific populations like the elderly. It offers advantages compared to other sodium channel blockers.

Keywords:
antiepileptic drugsepilepsy treatmentlacosamidemonotherapypolytherapysodium channel blockersvimpat

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Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Medicine

Background:

  • Focal epilepsy requires effective and tolerable antiepileptic drugs.
  • Lacosamide (LCM) emerged as a significant option for epilepsy management.
  • Understanding LCM's efficacy and tolerability is crucial for clinical practice.

Purpose of the Study:

  • To review significant studies on lacosamide's efficacy and tolerability in focal epilepsy.
  • To analyze LCM's performance in monotherapy and polytherapy, including long-term use.
  • To compare LCM with other sodium channel blockers and assess its clinical utility.

Main Methods:

  • Systematic review of key studies on lacosamide.
  • Analysis of data on efficacy, tolerability, and treatment retention.
  • Comparative assessment against other antiepileptic drugs.

Main Results:

  • Lacosamide demonstrates significant efficacy and good tolerability in focal epilepsy.
  • Positive outcomes observed in long-term use and treatment retention.
  • LCM shows specific advantages in elderly patients and certain combinations.

Conclusions:

  • Lacosamide is a valuable option for focal epilepsy treatment.
  • Its favorable profile supports its continued use and consideration in treatment strategies.
  • Further research can refine its role in comparison to other antiepileptic drugs.