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Related Experiment Video

Updated: Feb 20, 2026

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Platelets and Multi-Organ Failure in Sepsis.

Elisabetta Greco¹, Enrico Lupia², Ornella Bosco³

¹Department of Medical Science, University of Turin, 10126 Turin, Italy. betta.greco5@gmail.com.

International Journal of Molecular Sciences

|October 21, 2017

Summary

Platelets play an active role in sepsis-induced organ failure. Understanding platelet function in sepsis is crucial for developing new therapeutic strategies targeting this critical condition.

Keywords:

AKI ARDS DIC antiplatelets multi-organ failure platelet sepsis septic shock thrombocytopenia

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Area of Science:

Immunology
Hematology
Pathophysiology

Background:

Platelets are increasingly recognized for their involvement in infectious diseases, inflammation, and immunity.
Low platelet count is a known biomarker for sepsis severity.
Platelets are implicated in the pathogenesis of multi-organ failure during sepsis.

Purpose of the Study:

To review the pathogenic role of platelets in septic organ dysfunction.
To highlight platelets as potential therapeutic targets in sepsis.

Main Methods:

Literature review of human and animal studies on platelets in sepsis.
Analysis of the role of platelets at the intersection of immunity, coagulation, and endothelial cells.

Main Results:

Platelets actively contribute to the pathogenesis of septic organ dysfunction.
Platelets are central mediators in the complex response to sepsis.

Conclusions:

Platelets are key players in the development of organ injury during sepsis.
Targeting platelet function presents a promising therapeutic avenue for sepsis management.