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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Feb 20, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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Cell-based therapeutic strategies for multiple sclerosis.

Neil J Scolding1, Marcelo Pasquini2, Stephen C Reingold3

  • 1Department of Neurology, University of Bristol Southmead Hospital, Bristol BS10 5NB, UK.

Brain : a Journal of Neurology
|October 21, 2017
PubMed
Summary
This summary is machine-generated.

Cell-based therapies offer promising new avenues for multiple sclerosis (MS) treatment, potentially modulating the immune system and promoting neural repair. Further research and standardized clinical trials are essential to address safety and efficacy.

Keywords:
clinical trialsmedical ethicsmultiple sclerosis and neuroinflammationremyelinationstem cells

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Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) therapy has advanced with disease-modifying drugs, yet they only partially prevent CNS damage and do not promote repair.
  • Existing treatments for MS lack the ability to repair damaged neural tissue.

Purpose of the Study:

  • To review the current status of cell-based therapies for multiple sclerosis (MS).
  • To provide consensus recommendations for future research and clinical trials involving cell-based therapies in MS.

Main Methods:

  • Review of existing literature on cell-based therapies for MS.
  • Analysis of potential advantages, safety concerns, and methodological/ethical issues in clinical trials.

Main Results:

  • Cell-based therapies, including stem cell transplantation and progenitor cell transplantation, show promise for immune modulation, neuroprotection, and repair in MS.
  • Various cell-based approaches present distinct benefits alongside safety considerations and unresolved questions.

Conclusions:

  • Cell-based therapies represent a significant area of interest for novel MS treatment strategies.
  • Standardized research protocols and ethical considerations are crucial for advancing cell-based therapies in MS clinical trials.