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Updated: Feb 20, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
A Bitter Tale of Sweet Synergy
1Center for Smell and Taste, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Florida, Gainesville, FL 32610, USA.
Abstract:
Some sweeteners show a synergistic enhancement of perceived sweetness when they are tasted as binary mixtures. In this issue of Cell Chemical Biology, Behrens et al. (2017) find that a surprising explanation for this classic observation may lie in their reciprocal inhibition of bitter taste receptors.
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