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Related Experiment Video

Updated: Jun 11, 2026

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

Multiscale 3D Genome Rewiring during Mouse Neural Development.

Boyan Bonev¹, Netta Mendelson Cohen², Quentin Szabo¹

¹Institute of Human Genetics, UMR 9002 of the CNRS and the Université de Montpellier, 34396 Montpellier, France.

|October 21, 2017

Summary

This summary is machine-generated.

This study maps genome folding during neural development, revealing how 3D chromatin organization impacts gene expression and cell fate. Key findings link transcription to chromatin insulation and dynamic interactions during differentiation.

Keywords:

3D genome architecture Hi-C Polycomb cortical development enhancers neural differentiation transcription transcription factors

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Published on: March 8, 2024

Area of Science:

Genomics
Developmental Biology
Epigenetics

Background:

Chromosome conformation capture (3C) technologies provide insights into genome folding.
The relationship between 3D genome architecture, gene expression, and cell fate is not fully understood.

Purpose of the Study:

To comprehensively map 3D chromatin organization during mouse neural differentiation.
To investigate the dynamics of genome folding in relation to gene expression and cell fate determination.

Main Methods:

Generation of high-resolution Hi-C maps.
Analysis of chromatin organization during in vitro and in vivo neural differentiation.
Investigation of Polycomb network dynamics and transcription factor interactions.

Main Results:

Transcription correlates with chromatin insulation and long-range interactions.
dCas9-mediated activation does not create new TAD boundaries.
Long-range contacts exist between active gene bodies across cell types.
Active TAD contacts decrease, while inactive TAD contacts increase during neural differentiation.
Polycomb network disassembles, and neural transcription factor interactions emerge.
Cell type-specific enhancer-promoter contacts form with gene expression.

Conclusions:

Multiple factors dynamically influence chromatin interactions during neural development.
3D genome organization plays a crucial role in regulating gene expression and cell fate.
Developmental transitions involve significant remodeling of chromatin architecture.