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Updated: Feb 20, 2026

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

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Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification.

Lucia Tamborini¹, Pedro Fernandes², Francesca Paradisi³

¹Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milano, Italy.

Trends in Biotechnology

|October 22, 2017

Summary

This summary is machine-generated.

Biocatalysis using flow reactors offers improved performance for enzymes and whole-cell systems. This review explores the state-of-the-art, successes, and challenges of this enabling technology for broader applications.

Keywords:

biocatalysis biocatalyst immobilization continuous flow reactor process intensification

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Area of Science:

Biotechnology
Chemical Engineering
Biocatalysis

Background:

Advances in molecular tools have expanded biocatalysis scope.
Low productivity and scale-up challenges hinder current applications.
Flow reactors present a practical solution for enhancing biocatalyst performance.

Purpose of the Study:

To review the current state of biocatalysis in flow reactors.
To critically discuss successes and challenges of this technology.
To highlight opportunities and future technological advances.

Main Methods:

Review of existing literature on biocatalysis in flow systems.
Analysis of design principles for biocatalytic flow reactors.
Critical discussion of performance improvements and scale-up.

Main Results:

Biocatalysis in flow reactors shows significant performance improvements.
Enabling technology addresses limitations of traditional batch processes.
Successful applications demonstrate the potential of flow biocatalysis.

Conclusions:

Flow reactors are a key enabling technology for advancing biocatalysis.
Further research is needed to overcome remaining scale-up and productivity challenges.
Continued innovation in reactor design and biocatalyst engineering will drive future applications.