Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.1K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.6K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.7K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic footwear in patients with diabetes: a position statement from the Italian diabetic foot study group.

Acta diabetologica·2026
Same author

Optimized probe-ultrasound-assisted extraction of Chlorogenic acids from eggplant (Solanum melongena L.) by-products: Unlocking the phenolic and antioxidant potential of Calyx and leaves.

Food chemistry·2026
Same author

Nutrigenomics of fat-soluble vitamins and micronutrients in hepatocyte lipotoxicity and MASLD.

Progress in lipid research·2026
Same author

Effect of Recombinant NGF Encapsulated in Chitosan on Rabbit Sperm Traits and Main Metabolic Pathways.

Biology·2025
Same author

Identifying effective surveillance measures for swine pathogens using contact networks and mathematical modeling.

PloS one·2025
Same author

Dual pathway inhibition versus antiplatelet therapy for "symptomatic" lower-extremities peripheral artery disease in diabetes mellitus: a systematic review and a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome.

Acta diabetologica·2025
Same journal

Cancer immunotherapy with oncolytic myxoma virus.

Advances in cancer research·2026
Same journal

Cancer terminator viruses: Unique conditionally replication competent oncolytic viruses producing therapeutic anti-cancer immunomodulating agents.

Advances in cancer research·2026
Same journal

Advancing clinical translation of oncolytic adenoviruses.

Advances in cancer research·2026
Same journal

Operation oncolysis: Reoviruses in the theater of cancer war.

Advances in cancer research·2026
Same journal

AAV vectors for cancer gene therapy.

Advances in cancer research·2026
Same journal

Vesicular stomatitis virus (VSV) as an oncolytic therapeutic agent for cancer.

Advances in cancer research·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.9K

Selenium and Cancer Stem Cells.

Giuseppe Murdolo1, Desirée Bartolini2, Cristina Tortoioli1

  • 1Section of Internal Medicine, Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy.

Advances in Cancer Research
|October 22, 2017
PubMed
Summary
This summary is machine-generated.

Selenium (Se) compounds influence cancer stem cells (CSCs) by modulating redox pathways. Further research is needed to determine optimal Se compounds and concentrations for cancer therapy.

Keywords:
ApoptosisCancerCancer stem cellsOxidative stressReactive oxygen speciesSeleniumWnt/β-catenin

More Related Videos

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K

Related Experiment Videos

Last Updated: Feb 20, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.9K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K

Area of Science:

  • Biochemistry
  • Oncology
  • Nutritional Science

Background:

  • Selenium (Se) is an essential micronutrient with crucial roles in cellular redox balance and homeostasis.
  • Epidemiological and experimental studies suggest potential health benefits of both inorganic and organic Se forms.
  • The role of Se compounds in cancer prevention and treatment remains controversial, with ongoing investigation into their effects on cancer stem cells (CSCs).

Purpose of the Study:

  • To review the current understanding of Selenium's effects on cancer stem cells (CSCs).
  • To focus on redox-dependent pathways and gene regulation checkpoints influencing CSC self-renewal, differentiation, and migration.
  • To highlight the potential of Se compounds in cancer therapy by targeting CSCs.

Main Methods:

  • Literature review summarizing current knowledge on Se compounds and CSCs.
  • Focus on redox-dependent signaling pathways.
  • Analysis of gene regulation checkpoints affecting CSC behavior.

Main Results:

  • Se compounds modulate numerous signaling pathways critical for CSC biology.
  • Evidence suggests Se compounds can influence CSC self-renewal, differentiation, and migration.
  • Redox regulation plays a key role in the effects of Se on CSCs.

Conclusions:

  • Selenium compounds show potential in modulating cancer stem cell behavior.
  • Targeting CSCs with Se compounds may offer a novel therapeutic strategy.
  • Further research is required to optimize Se concentrations and identify cancer-specific compounds for effective treatment.