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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Related Experiment Video

Updated: Feb 20, 2026

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

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Selenoproteins and Metastasis.

Michael P Marciel1, Peter R Hoffmann1

  • 1John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.

Advances in Cancer Research
|October 22, 2017
PubMed
Summary

Selenoproteins are crucial in cancer metastasis, influencing cell movement, invasion, and growth. Understanding their roles offers new targets for antimetastatic therapies to improve cancer survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Metastasis, the spread of cancer cells, significantly impacts patient survival.
  • Antimetastatic therapies are a research focus, necessitating deeper understanding of metastasis mechanisms.
  • Selenoproteins are implicated in key cellular processes driving metastasis.

Purpose of the Study:

  • To review the multifaceted roles of selenoproteins in cancer metastasis.
  • To explore how different selenoproteins may promote or inhibit metastatic progression.
  • To highlight selenoproteins as potential therapeutic targets.

Main Methods:

  • Literature review of studies on selenoproteins and metastasis.
  • Analysis of selenoprotein functions in cellular adhesion, migration, invasion, and angiogenesis.
Keywords:
AngiogenesisAntioxidantCalcium fluxCancerMigrationRedoxSelenium

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  • Discussion of redox modulation, calcium homeostasis, and unfolded protein responses.

    • Main Results:

    • Selenoproteins are involved in cell adhesion, matrix degradation, migration, and invasion.
    • Endoplasmic reticulum selenoproteins regulate calcium homeostasis and unfolded protein responses.
    • Selenoproteins modulate cellular redox tone and detoxification pathways.

    Conclusions:

    • Selenoproteins play diverse and critical roles throughout the metastatic cascade.
    • Targeting selenoproteins presents a promising strategy for developing novel antimetastatic treatments.
    • Further research into selenoprotein function can enhance cancer survival outcomes.