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Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Heart Failure II: Pathophysiology01:29

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pathophysiology of Cardiac Performance01:29

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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Heart Failure I: Introduction01:27

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Related Experiment Video

Updated: Feb 20, 2026

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
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Mechanisms driving the ageing heart.

Rhys Anderson1, Gavin D Richardson2, João F Passos3

  • 1The Randall Division, King's College London, London, UK; Ageing Research Laboratories, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK; Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.

Experimental Gerontology
|October 22, 2017
PubMed
Summary

Cellular senescence, an irreversible cell-cycle arrest, is increasingly linked to heart ageing and cardiovascular disease (CVD). Targeting senescent cells may offer a novel therapeutic strategy for age-related heart conditions.

Keywords:
DNA damage responseMitochondriaReactive oxygen speciesSenescenceTelomeres

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Related Experiment Videos

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Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Cell Biology

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Age is a primary risk factor for CVD, yet cardiac ageing mechanisms remain unclear.
  • Understanding heart ageing is crucial for developing effective preventions and treatments.

Purpose of the Study:

  • To review the current understanding of cellular senescence in heart ageing.
  • To elucidate the mechanisms by which senescence impacts cardiac ageing and CVD.
  • To evaluate senolytics as a potential therapy for age-related cardiac dysfunction.

Main Methods:

  • Literature review of cellular senescence and cardiovascular ageing.
  • Analysis of mechanisms linking senescence pathways to heart ageing.
  • Evaluation of emerging data on senolytic therapies for cardiac ageing.

Main Results:

  • Cellular senescence is implicated in the ageing of the heart.
  • Specific cell types and mechanisms of senescence in the heart require further elucidation.
  • Targeting senescent cells shows promise as a therapeutic approach.

Conclusions:

  • Cellular senescence is a significant contributor to cardiac ageing and CVD.
  • Further research is needed to identify specific senescent cell types and mechanisms in the heart.
  • Therapeutic strategies targeting senescent cells warrant investigation for combating heart ageing.