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[Clinical evaluation of drug interactions of cyclosporin]
E M Billaud1, C Kreft-Jais, F De la Tour du Pin
1Service de Pharmacologie clinique, Hôpital Broussais, Paris.
Presse Medicale (Paris, France : 1983)
|December 3, 1988
Abstract:
Cyclosporin is a nephrotoxic immunosuppressant metabolized in the liver and requiring drug monitoring. Numerous pharmacokinetic and pharmacodynamic drug interactions have occurred with this compound. Some of them are well substantiated while others are merely suspected. The major interactions must definitely be prevented of corrected, whereas the others need no more than careful drug monitoring.