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Frequency-dependent selection, metrical characters and molecular evolution.

B C Clarke1, P R Shelton, G S Mani

  • 1Department of Genetics, Queen's Medical Centre, Nottingham, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|July 6, 1988
PubMed
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Computer models reveal that combining frequency-dependent and stabilizing selection maintains genetic diversity. Random mutation order drives significant evolutionary effects, impacting divergence and evolution rates.

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Quantitative genetics

Background:

  • Maintaining genetic polymorphism is crucial for adaptation.
  • Understanding the interplay between selection types and mutation order is key to evolutionary dynamics.

Purpose of the Study:

  • To model the effects of combined selection types on quantitative traits.
  • To investigate the role of mutation order in evolutionary stochasticity.
  • To explain patterns of divergence and differing evolutionary rates.

Main Methods:

  • Development and analysis of computer simulations.
  • Modeling frequency-dependent and stabilizing selection.
  • Incorporating the impact of random mutation order.

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Main Results:

  • Combined selection effectively maintains numerous polymorphisms.
  • Selectively driven stochastic effects from mutation order can outweigh genetic drift.
  • Models explain inter-population divergence and discrepancies in morphological vs. molecular evolution rates.

Conclusions:

  • Frequency-dependent and stabilizing selection are powerful forces for maintaining genetic diversity.
  • Mutation order is a significant, often underestimated, factor in evolution.
  • These findings offer a selective basis for understanding molecular clock rates.