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Merkel cell carcinoma with fingolimod treatment for multiple sclerosis: A case report
Kedar R Mahajan1, Jennifer S Ko2, Michael T Tetzlaff3
1Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, USA.
Multiple Sclerosis and Related Disorders
|October 23, 2017
Abstract:
Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with multiple sclerosis who developed MCPyV-positive MCC 4 years after starting fingolimod. This is the second report of MCC associated with MCPyV in an individual on fingolimod.
