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PER3 VNTR polymorphism in Multiple Sclerosis: A new insight to impact of sleep disturbances in MS

Masoud Golalipour1, Zahra Maleki2, Touraj Farazmandfar1

  • 1Medical Cellular and Molecular Research center, Golestan University of Medical Sciences, Gorgan, Iran.

Multiple Sclerosis and Related Disorders
|October 23, 2017
PubMed
Abstract

Insights

The PER3 4/4 genotype is linked to an increased risk and earlier onset of Multiple Sclerosis (MS). This finding suggests PER3 gene variants may influence MS disease progression.

Area of Science:

  • Neuroimmunology
  • Genetics
  • Sleep Medicine

Background:

  • Multiple Sclerosis (MS) is a central nervous system autoimmune disease affecting myelin.
  • Sleep disturbances are common in MS patients, impacting quality of life.
  • Circadian rhythm genes, like PER3, influence both sleep and immune responses.

Purpose of the Study:

  • To investigate the association between the PER3 VNTR polymorphism and Multiple Sclerosis (MS).
  • To explore the potential role of PER3 gene variants in MS susceptibility and disease characteristics.

Main Methods:

  • Genotyping of the PER3 VNTR polymorphism in 160 MS patients and 160 healthy controls using PCR.
  • Statistical analysis of genotypic and allelic distributions using the chi-square test.

Main Results:

  • A significant association was found between the PER3 4/4 genotype and the 4-repeat allele with MS.
  • The PER3 4/4 genotype correlated significantly with female gender and earlier MS onset.
  • p-values indicated strong statistical significance for these associations (p=0.014, p<0.001, p=0.033, p=0.028).

Conclusions:

  • The PER3 4/4 genotype may be a risk factor for developing MS.
  • This genotype might accelerate disease progression in individuals susceptible to MS.
  • PER3 gene variants warrant further investigation in the context of MS pathogenesis and clinical course.
Keywords:
Circadian rhythmMultiple SclerosisPER3VNTR polymorphism

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