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The relationship between fibrinogen and in-hospital mortality in patients with type A acute aortic dissection

Jun Liu1, Lian-Lian Sun1, Jue Wang2

  • 1Division of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.

The American Journal of Emergency Medicine
|October 23, 2017
PubMed

Insights

Low fibrinogen levels on admission predict higher in-hospital mortality in patients with type A acute aortic dissection (AAD). This finding highlights fibrinogen

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Critical Care Medicine

Background:

  • Fibrinogen is crucial for hemostasis and thrombosis.
  • Fibrinogen levels have prognostic value in cardiovascular diseases.

Purpose of the Study:

  • To evaluate fibrinogen as a prognostic indicator in type A acute aortic dissection (AAD).

Main Methods:

  • Consecutive patients with type A AAD within 24 hours of symptom onset were studied.
  • Fibrinogen levels were measured on admission.
  • In-hospital mortality was the primary endpoint.

Main Results:

  • 143 patients with type A AAD were analyzed.
  • Nonsurvivors had significantly lower fibrinogen levels (1.95 g/L) compared to survivors (2.37 g/L).
  • An admission fibrinogen level < 2.17 g/L was independently associated with increased in-hospital mortality (OR 5.527).

Conclusions:

  • Low admission fibrinogen levels are an independent predictor of in-hospital mortality in type A AAD patients.
Abstract

Keywords:
Aortic dissectionFibrinogenIn-hospital death

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