Related Experiment Video

Updated: Feb 20, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K

Prospective memory in bipolar disorder: A meta-analysis

Fu-Chun Zhou1, Yuan-Yuan Wang2, Wei Zheng3

  • 1Department of Psychiatry, Beijing Anding Hospital, Capital Medical University & Beijing Key Laboratory of Mental Disorders & The National Clinical Research Center for Mental Disorders, China & Beijing Institute for Brain Disorders Center of Schizophrenia; Beijing, China.

Psychiatry Research
|October 23, 2017
PubMed

Insights

Patients with bipolar disorder exhibit significant prospective memory (PM) deficits. This meta-analysis confirms impairments in both event-based and time-based PM compared to healthy individuals.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Conflicting findings exist regarding prospective memory (PM) performance in bipolar disorder.
  • PM involves remembering to perform intended actions in the future.
  • Bipolar disorder is associated with various cognitive impairments.

Purpose of the Study:

  • To systematically examine and meta-analyze prospective memory performance in patients with bipolar disorder.
  • To compare PM deficits in bipolar disorder patients versus healthy controls.

Main Methods:

  • Systematic literature search in English and Chinese databases up to November 2016.
  • Inclusion of case-control studies comparing PM in bipolar disorder patients and healthy controls.
  • Random effects model meta-analysis of four included studies (n=390).

Main Results:

  • Bipolar disorder patients demonstrated significant impairments in overall PM (SMD: -1.08), event-based PM (SMD: -0.51), and time-based PM (SMD: -0.82) compared to controls.
  • Evidence quality for meta-analyzable outcomes ranged from moderate to high.
  • Included studies were of moderate to high quality.

Conclusions:

  • Both time-based and event-based prospective memory deficits are evident in individuals with bipolar disorder.
  • These findings highlight significant cognitive challenges in bipolar disorder patients.
  • Further research may explore interventions targeting PM deficits.
Keywords:
Bipolar disorderMeta-analysisProspective memory

More Related Videos

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection11:30

Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection

Published on: August 26, 2011

10.4K
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

14.1K

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.1K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
677
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
620
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
975
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
762