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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Spirooxindoles as Potential Pharmacophores
Siva S Panda1, Rachel A Jones2, Praveen Bachawala3
1Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, United States.
Objective:
The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
Background:
Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion:
The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
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