Related Experiment Video For 5-Aminolevulinic acid
Updated: Feb 20, 2026
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based
Yusei Shinohara1, Yoshio Endo2, Chiaki Abe3
1Graduate School of Advanced Technology and Science, Tokushima University, Tokushima, Japan.
Abstract:
5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various cancers. Recently, we found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer. TX-816 might be a useful compound for designing prodrug-type ALA-PDT enhancers.
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