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A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
Interpreting diagnostic tests with continuous results and no gold standard: a common scenario explained using the
Claudia C Dobler1, M Hassan Murad1
1Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota, USA.
Abstract:
Practitioners of evidence-based medicine commonly encounter diagnostic tests with continuous results and no gold standard. In contrast, the traditional critical appraisal teachings assume a binary test (2×2 table) with a gold standard. In this guide, we use the example of the tuberculin skin test to illustrate a simple approach facilitated by using stratum-specific likelihood ratios and odds of developing future patient-important events. This approach can aid practitioners in the interpretation and application of diagnostic tests to patient care.
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