Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Principles of Disease Surveillance01:26

Principles of Disease Surveillance

609
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
609
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.4K
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

928
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
928
Other Unique Bacteria01:18

Other Unique Bacteria

493
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
493
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

2.9K
A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
2.9K
Introduction to Epidemiology01:26

Introduction to Epidemiology

2.0K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antagonism of stress granules key for SARS-CoV-2 infection and pathogenesis.

bioRxiv : the preprint server for biology·2026
Same author

Flea infestation and molecular detection of Rickettsia and Bartonella spp. in domestic dog-associated fleas from the inter-Andean basin of Cundinamarca, Colombia.

Medical and veterinary entomology·2026
Same author

Investigation of neglected bacterial pathogens provides molecular and serological evidence of Bartonella spp. in patients with acute undifferentiated febrile illness in Villeta, Colombia.

Parasites & vectors·2026
Same author

The Paucity of Typical Pathology: An Autopsy Series of Typhus Group Rickettsiosis-Associated Hemophagocytic Lymphohistiocytosis.

Pathogens (Basel, Switzerland)·2026
Same author

From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum.

Nature communications·2026
Same author

A Case Cluster Conundrum of Flea-Borne Rickettsiosis: Is Rickettsia felis or Rickettsia typhi to Blame?

Military medicine·2026

Related Experiment Video

Updated: Feb 20, 2026

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

12.5K

Ehrlichioses: An Important One Health Opportunity.

Tais B Saito1, David H Walker2

  • 1Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. tbsaito@utmb.edu.

Veterinary Sciences
|October 24, 2017
PubMed
Summary

Ehrlichioses are severe tick-borne bacterial infections. While the immune system controls infection in some hosts, it can cause fatal inflammation or overwhelming disease in others, complicating vaccine development.

Keywords:
Ehrlichia canisEhrlichia chaffeensisEhrlichia ewingiiEhrlichia murisEhrlichia ruminantiumcanine ehrlichiosisheartwaterhuman ehrlichiosisimmunopathologymouse models

More Related Videos

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
08:58

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

9.5K
Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.7K

Related Experiment Videos

Last Updated: Feb 20, 2026

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

12.5K
Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test
08:58

Enhanced Rabies Surveillance Using a Direct Rapid Immunohistochemical Test

Published on: April 30, 2019

9.5K
Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.7K

Area of Science:

  • Veterinary Medicine
  • Immunology
  • Microbiology

Background:

  • Ehrlichioses are intracellular bacterial infections transmitted by ticks.
  • Severe illness occurs in incidental hosts, often due to host immune responses.
  • Ehrlichia manipulate host cells via secreted proteins.

Purpose of the Study:

  • To review the pathogenesis of ehrlichioses.
  • To discuss the role of the immune system in disease severity and control.
  • To highlight challenges in vaccine development.

Main Methods:

  • Review of existing literature on Ehrlichia pathogenesis and host immune responses.
  • Analysis of immune mechanisms contributing to disease and protection.
  • Identification of factors hindering vaccine development.

Main Results:

  • Severe ehrlichiosis involves immune overproduction of cytokines like tumor necrosis factor α (TNF-α) and interleukin-10 (IL-10).
  • Both protective and pathogenic roles are observed for immune components like CD8 T cells and TNF-α.
  • Immunocompetent hosts may succumb to excessive inflammation, while immunodeficient hosts face overwhelming infection.

Conclusions:

  • Host immune responses play a dual role in Ehrlichia infections, leading to severe disease or control.
  • Vaccine development for Ehrlichia ruminantium is hindered by antigenic variation and the risk of immunopathology.