Related Experiment Video
Updated: Feb 20, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling
Dana K Shaw1, Erin E McClure2, Xiaowei Wang3
1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. dshaw@som.umaryland.edu.
Abstract:
In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.
Related Concept Videos
The JAK-STAT Signaling Pathway
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
Bacterial Phylum Spirochaetes
Intracellular Movement of Viruses and Bacteria
Bacterial Signaling
Inflammation

