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Updated: Feb 20, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
The miracle of peer review and development in science: an agent-based model
Simone Righi1,2, Károly Takács2
1Department of Agricultural and Food Sciences, Alma Mater Studiorum - University of Bologna, Viale Fanin 50, 40127 Bologna, Italy.
Abstract:
It is not easy to rationalize how peer review, as the current grassroots of science, can work based on voluntary contributions of reviewers. There is no rationale to write impartial and thorough evaluations. If reviewers are unmotivated to carefully select high quality contributions, there is no risk in submitting low-quality work by authors. As a result, scientists face a social dilemma: if everyone acts according to his or her own self-interest, the outcome is low scientific quality. We examine how the increased relevance of public good benefits (journal impact factor), the editorial policy of handling incoming reviews, and the acceptance decisions that take into account reputational information, can help the evolution of high-quality contributions from authors. High effort from the side of reviewers is problematic even if authors cooperate: reviewers are still best off by producing low-quality reviews, which does not hinder scientific development, just adds random noise and unnecessary costs to it. We show with agent-based simulations why certain self-emerged current practices, such as the increased reliance on journal metrics and the reputation bias in acceptance, work efficiently for scientific development. Our results find no proper guidelines, however, how the system of voluntary peer review with impartial and thorough evaluations could be sustainable jointly with rapid scientific development.
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