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Related Experiment Video

Updated: Feb 20, 2026

Setting a Successful Sorting for Extracellular Vesicle Isolation
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Stem-cell extracellular vesicles and lung repair.

Fernanda F Cruz1, Patricia R M Rocco1

  • 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, and National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, RJ, Brazil.

Stem Cell Investigation
|October 24, 2017
PubMed
Summary

Mesenchymal stromal cell-derived extracellular vesicles show promise for treating lung diseases and critical illness by reducing inflammation and fibrosis. Ongoing clinical trials are investigating their therapeutic potential.

Keywords:
Extracellular vesicles (EVs)exosomeslung diseasesmicrovesiclesregenerative medicine

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Area of Science:

  • Pulmonary Medicine
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Lung diseases are a major global health burden, with limited effective treatments.
  • Current therapies often fail to halt disease progression or reverse lung damage.
  • Cell therapy is emerging as a potential treatment strategy for respiratory disorders.

Purpose of the Study:

  • To review the role of extracellular vesicles (EVs) from mesenchymal stromal cells (MSCs) in lung diseases.
  • To discuss preclinical and clinical evidence for MSC-derived EVs in treating pulmonary disorders and critical illness.

Main Methods:

  • Literature review of preclinical studies and clinical trials.
  • Focus on the therapeutic mechanisms of MSC-derived EVs, including their secretome components.
  • Analysis of the anti-inflammatory, antifibrotic, and microbicidal effects.

Main Results:

  • MSC-derived EVs possess therapeutic properties attributed to their cargo (proteins, microRNAs, mRNAs).
  • Preclinical models demonstrate the efficacy of EVs in various lung injury and disease contexts.
  • Clinical trials are underway to evaluate the safety and effectiveness of these EVs.

Conclusions:

  • MSC-derived EVs represent a promising cell-free therapeutic approach for lung diseases.
  • Further research and clinical evaluation are crucial to establish EVs as a standard treatment.
  • EVs offer a potential alternative to cell-based therapies with enhanced safety and scalability.